Article
Functional rescue of the sarcoglycan complex in the BIO 14.6 hamster using delta-sarcoglycan gene transfer.
Molecular cell - 1 May 1998
Holt K H, Lim L E, Straub V, Venzke D P, Duclos F, Anderson R D, Davidson B L, Campbell K P
Abstract excerpt
Four types of limb-girdle muscular dystrophy (LGMD) are known to be caused by mutations in distinct sarcoglycan genes. The BIO 14.6 hamster is a model for sarcoglycan-deficient LGMD with a deletion in the delta-sarcoglycan (delta-SG) gene. We investigated the function of the sarcoglycan complex a...
Topics
- Adenoviridae
- Animals
- Cricetinae
- Cytoskeletal Proteins
- Gene Transfer Techniques
- Humans
- Injections, Intramuscular
- Male
- Membrane Glycoproteins
- Microinjections
- Muscle Fibers, Skeletal
- Muscle, Skeletal
- Muscular Dystrophy, Animal
- Mutation
- Plasmids
- Recombinant Proteins
- Sarcoglycans
- Sarcolemma