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Article

Functional rescue of the sarcoglycan complex in the BIO 14.6 hamster using delta-sarcoglycan gene transfer.

Molecular cell - 1 May 1998

Holt K H, Lim L E, Straub V, Venzke D P, Duclos F, Anderson R D, Davidson B L, Campbell K P

Abstract excerpt

Four types of limb-girdle muscular dystrophy (LGMD) are known to be caused by mutations in distinct sarcoglycan genes. The BIO 14.6 hamster is a model for sarcoglycan-deficient LGMD with a deletion in the delta-sarcoglycan (delta-SG) gene. We investigated the function of the sarcoglycan complex and the feasibility of sarcoglycan gene transfer for LGMD using a recombinant delta-SG adenovirus in the BIO 14.6...

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PMID: 9660967
DOI: 10.1016/s1097-2765(00)80083-0

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