Article
The genetic predisposition of natural killer cell to BK virus-associated nephropathy in renal transplant patients.
Kidney international - 1 Aug 2013
Trydzenskaya Hanna, Juerchott Karsten, Lachmann Nils, Kotsch Katja, Kunert Kristina, Weist Benjamin, Schönemann Constanze, Schindler Ralf, Nickel Peter, Melzig Matthias F, Hugo Christian, Thomusch Oliver, Neumann Avidan U, Reinke Petra, Babel Nina
Abstract excerpt
BK virus (BKV) infection represents a serious complication in renal transplant patients resulting in BKV-associated nephropathy and subsequent allograft loss. Natural killer cells are crucial in the antiviral immune response; however, an understanding of the role of natural killer cells in protection against BKV is limited. To elucidate whether killer-cell immunoglobulin-like receptors and their interaction...
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