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Article

Stromal ColXα1 expression correlates with tumor-infiltrating lymphocytes and predicts adjuvant therapy outcome in ER-positive/HER2-positive breast cancer.

BMC cancer - 1 Nov 2019

Zhao Chaohui Lisa, Singh Kamaljeet, Brodsky Alexander S, Lu Shaolei, Graves Theresa A, Fenton Mary Anne, Yang Dongfang, Sturtevant Ashlee, Resnick Murray B, Wang Yihong

Abstract excerpt

BACKGROUND: The breast cancer microenvironment contributes to tumor progression and response to chemotherapy. Previously, we reported that increased stromal Type X collagen α1 (ColXα1) and low TILs correlated with poor pathologic response to neoadjuvant therapy in estrogen receptor and HER2-positive (ER+/HER2+) breast cancer. Here, we investigate the relationship of ColXα1 and long-term outcome of ER+/HER2+...

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Share to Chemotherapy, Adjuvant
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

Share to Lymphocytes, Tumor-Infiltrating

Share to Receptor, ErbB-2

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Source

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Identifiers

PMID: 31675929
DOI: 10.1186/s12885-019-6134-y
PMCID: PMC6825361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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