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Article

Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes

12 Oct 2019

Abstract excerpt

Cancer-associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen-binding integrin α11β1 has been proposed to be upregulated in a pro-tumorigenic subtype of cancer-associated fibroblasts. Here, we analyzed the expression and clinical relevance of integrin α11β1 in a large breast cancer series using a novel antibody against the human integrin α11 chain. Several novel monoclonal...

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PMID: 31605508
DOI: 10.1002/cjp2.148

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