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Article

Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas.

BMC cancer - 3 May 2017

Lehtinen Birgitta, Raita Annina, Kesseli Juha, Annala Matti, Nordfors Kristiina, Yli-Harja Olli, Zhang Wei, Visakorpi Tapio, Nykter Matti, Haapasalo Hannu, Granberg Kirsi J

Abstract excerpt

BACKGROUND: Fibroblast growth factor receptors (FGFRs) are well-known proto-oncogenes in several human malignancies and are currently therapeutically targeted in clinical trials. Among glioma subtypes, activating FGFR1 alterations have been observed in a subpopulation of pilocytic astrocytomas while FGFR3 fusions occur in IDH wild-type diffuse gliomas, resulting in high FGFR3 protein expression. The purpose of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Fibroblast Growth Factor, Type 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 28468611
DOI: 10.1186/s12885-017-3274-9
PMCID: PMC5415775

Genes

FGFR3
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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