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Article

Differentiation of Induced Pluripotent Stem Cells towards Mesenchymal Stromal Cells is Hampered by Culture in 3D Hydrogels.

Scientific reports - 30 Oct 2019

Goetzke Roman, Keijdener Hans, Franzen Julia, Ostrowska Alina, Nüchtern Selina, Mela Petra, Wagner Wolfgang

Abstract excerpt

Directed differentiation of induced pluripotent stem cells (iPSCs) towards specific lineages remains a major challenge in regenerative medicine, while there is a growing perception that this process can be influenced by the three-dimensional environment. In this study, we investigated whether iPSCs can differentiate towards mesenchymal stromal cells (MSCs) when embedded into fibrin hydrogels to enable a one-step...

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Identifiers

PMID: 31666572
DOI: 10.1038/s41598-019-51911-5
PMCID: PMC6821810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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