Article
A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds.
Scientific reports - 1 Jan 2013
Zou Lijin, Luo Yonglun, Chen Muwan, Wang Gang, Ding Ming, Petersen Charlotte Christie, Kang Ran, Dagnaes-Hansen Frederik, Zeng Yuanlin, Lv Nonghua, Ma Qing, Le Dang Q S, Besenbacher Flemming, Bolund Lars, Jensen Thomas G, Kjems Jørgen, Pu William T, Bünger Cody
Abstract excerpt
We describe a simple method for bone engineering using biodegradable scaffolds with mesenchymal stem cells derived from human induced-pluripotent stem cells (hiPS-MSCs). The hiPS-MSCs expressed mesenchymal markers (CD90, CD73, and CD105), possessed multipotency characterized by tri-lineages differentiation: osteogenic, adipogenic, and chondrogenic, and lost pluripotency - as seen with the loss of markers OCT3/4...
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