Article

Optimizing the live attenuated influenza A vaccine backbone for high-risk patient groups

2021-10-06

Abstract excerpt

The live attenuated influenza vaccine (LAIV) is approved for intranasal spray application in 2-49 year-old patients with safety concerns limiting its use in younger children and immunocompromised patients, mainly from the higher incidence of adverse events and the possibility of uncontrolled replication and reversion to a pathogenic strain, respectively. Further attenuation of the LAIV could generally improve its...

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Literature Corpus work: 368ab380-d453-527d-8fe0-9ec87c86b483
DOI: 10.1101/2021.10.06.462766

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