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Article

Epigenetic switching as a strategy for quick adaptation while attenuating biochemical noise.

PLoS computational biology - 1 Oct 2019

Gómez-Schiavon Mariana, Buchler Nicolas E

Abstract excerpt

Epigenetic switches are bistable, molecular systems built from self-reinforcing feedback loops that can spontaneously switch between heritable phenotypes in the absence of DNA mutation. It has been hypothesized that epigenetic switches first evolved as a mechanism of bet-hedging and adaptation, but the evolutionary trajectories and conditions by which an epigenetic switch can outcompete adaptation through genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31658246
DOI: 10.1371/journal.pcbi.1007364
PMCID: PMC6837633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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