Morphofunctional Differences of Micronuclei in Cultures of Human p53-Positive and p53-Negative Tumor Cells.

Abstract excerpt

Micronuclei that are often present in tumor cells are not only the indicator of genetic instability, they also can induce DNA damage during cell progression through the cell cycle. p53 protein is the key regulator of the cell cycle. In this study we compared morphofunctional features of micronuclei depending on the presence of wild-type p53 gene: in human breast adenocarcinoma MCF-7 (p53+) and human epidermoid...

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