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Protein secretion in wild-type and Othac1 mutant strains of thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC656.

Molecular biology reports - 1 Jan 2020

Phithakrotchanakoon Chitwadee, Phaonakrop Narumon, Roytrakul Sittiruk, Tanapongpipat Sutipa, Roongsawang Niran

Abstract excerpt

In yeasts, Hac1 transcription factor of the unfolded protein response (UPR) regulates many genes involved in secretory pathways. The thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC656 is a host for heterologous protein secretion. To understand the role of OtHac1 on the secretome of O. thermomethanolica, a comparative proteomic analysis using LC-MS/MS was employed to identify proteins with...

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PMID: 31654213
DOI: 10.1007/s11033-019-05149-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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