Deleterious Variants in WNT10A, EDAR, and EDA Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations.

doi:10.3390/ijms20215282

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Article

Deleterious Variants in WNT10A, EDAR, and EDA Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations.

International journal of molecular sciences - 24 Oct 2019

Parveen Asia, Khan Sher Alam, Mirza Muhammad Usman, Bashir Hina, Arshad Fatima, Iqbal Maria, Ahmad Waseem, Wahab Ahsan, Fiaz Amal, Naz Sidra, Ashraf Fareeha, Mobeen Tayyaba, Aziz Salman, Ahmed Syed Shoaib, Muhammad Noor, Hassib Nehal F, Mostafa Mostafa I, Gaboon Nagwa E, Gul Roquyya, Khan Saadullah, Froeyen Matheus, Shoaib Muhammad, Wasif Naveed

Abstract excerpt

The dental abnormalities are the typical features of many ectodermal dysplasias along with congenital malformations of nails, skin, hair, and sweat glands. However, several reports of non-syndromic/isolated tooth agenesis have also been found in the literature. The characteristic features of hypohidrotic ectodermal dysplasia (HED) comprise of hypodontia/oligodontia, along with hypohidrosis/anhidrosis, and...

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PMID: 31652981
DOI: 10.3390/ijms20215282
PMCID: PMC6862269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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