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Whole exome sequencing uncovers key genetic variants in congenital tooth agenesis: an integrative omics approach.

Gene - 5 Nov 2026

Ranjan Prashant, Devi Chandra, Verma Neha, Bansal Rajesh, Srivastava Vinay Kumar, Kumari Rimjhim, Das Parimal

Abstract excerpt

PURPOSE: This study investigates the genetic basis of congenital tooth agenesis (CTA) using an omics approach. Whole exome sequencing (WES) identified novel variants, which were further analyzed in combination with RNA expression data to uncover genes associated with CTA, molecular mechanisms, and systemic disease links. METHODS: WES was performed on 11 samples (6 CTA patients and 5 controls) to identify...

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Anodontia
Ectodysplasins
Exome Sequencing
Gene Expression Profiling
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42336005
DOI: 10.1016/j.gene.2026.150278

Genes

OR4F21
WNT10A
EDA
LCORL
MAF
MRTFB
PAX9

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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