Article
Crystal structure and molecular dynamics simulation of ubiquitin-like domain of murine parkin.
Biochimica et biophysica acta - 1 Jan 2000
Tomoo Koji, Mukai Yasuhiro, In Yasuko, Miyagawa Hiroo, Kitamura Kunihiro, Yamano Akihito, Shindo Heisaburo, Ishida Toshimasa
Abstract excerpt
Parkin is the gene product identified as the major cause of autosomal recessive juvenile Parkinsonism (AR-JP). Parkin, a ubiquitin ligase E3, contains a unique ubiquitin-like domain in its N-terminus designated Uld which is assumed to be a interaction domain with the Rpn 10 subunit of 26S proteasome. To elucidate the structural and functional role of Uld in parkin at the atomic level, the X-ray crystal structure...
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