Article
The association between type of endocrine therapy and development of estrogen receptor-1 mutation(s) in patients with hormone-sensitive advanced breast cancer: A systematic review and meta-analysis of randomized and non-randomized trials.
Biochimica et biophysica acta. Reviews on cancer - 1 Dec 2019
Najim Omar, Seghers Sofie, Sergoynne Laurine, Van Gaver Hélène, Papadimitriou Konstantinos, Wouters Kristien, Trinh Xuan Bich, Huizing Manon T, Tjalma Wiebren
Abstract excerpt
BACKGROUND: Breast cancer has, due to its high incidence, the highest mortality of cancer in women. The most common molecular type of breast cancer is the luminal subtype, which expresses estrogen and progesterone receptors and is typically treated with surgery and adjuvant endocrine therapy (ET). Estrogen receptor alpha (ERα), encoded by the estrogen receptor-1 (ESR1) gene, is expressed in approximately 70% of...
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