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Article

HLA-B51:01 and CYP2C93 Are Risk Factors for Phenytoin-Induced Eruption in the Japanese Population: Analysis of Data From the Biobank Japan Project.

Clinical pharmacology and therapeutics - 1 May 2020

Hikino Keiko, Ozeki Takeshi, Koido Masaru, Terao Chikashi, Kamatani Yoichiro, Mizukawa Yoshiko, Shiohara Tetsuo, Tohyama Mikiko, Azukizawa Hiroaki, Aihara Michiko, Nihara Hiroyuki, Morita Eishin, Murakami Yoshinori, Kubo Michiaki, Mushiroda Taisei

Abstract excerpt

CYP2C9*3 and HLA-B alleles are reportedly associated with phenytoin-induced eruption in some East Asian populations; however, this finding is not readily applicable to the Japanese population. Thus, we aimed to investigate the risk alleles using samples and data from BioBank Japan. A total of 747 patients (24 cases and 723 tolerant controls) were selected for analysis. Case-control association studies were...

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Identifiers

PMID: 31646624
DOI: 10.1002/cpt.1706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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