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Amyloid-β Oligomers-induced Mitochondrial DNA Repair Impairment Contributes to Altered Human Neural Stem Cell Differentiation

23 Oct 2019

Abstract excerpt

BACKGROUND: Amyloid-β42 oligomers (Aβ42O), the proximate effectors of neurotoxicity observed in Alzheimer's disease (AD), can induce mitochondrial oxidative stress and impair mitochondrial function besides causing mitochondrial DNA (mtDNA) damage. Aβ42O also regulate the proliferative and differentiative properties of stem cells. OBJECTIVE: We aimed to study whether Aβ42O-induced mtDNA damage is involved in the...

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PMID: 31642778
DOI: 10.2174/1567205016666191023104036

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