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The Effect of In Vitro Hemolysis on Measurement of Cell-Free DNA

25 Jun 2019

Abstract excerpt

BACKGROUND: Hemolysis during blood drawing is a common cause of laboratory artifacts. Although circulating cell-free tumor DNA and fetal DNA are currently measured in routine practice, the effect of in vitro hemolysis on the measurement of cell-free DNA (cfDNA) has not been investigated. When in vitro hemolysis occurs, cellular DNA could be released from damaged white blood cells and reduce the fraction of...

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PMID: 31639669
DOI: 10.1373/jalm.2018.027953

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