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Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA

14 Aug 2025

Abstract excerpt

Platelets are anucleate blood cells vital for hemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release DNA, resulting in "cell-free" DNA in plasma (cfDNA). An excess of cfDNA is deleterious. Given their ability to internalize pathogen-derived nucleic acids, we hypothesized that platelets may also clear endogenous cfDNA. We found that, despite lacking a nucleus, platelets contained...

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PMID: 40811534
DOI: 10.1126/science.adp3971

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