Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New role for crinamine as a potent, safe and selective inhibitor of human monoamine oxidase B: In vitro and in silico pharmacology and modeling.

Journal of ethnopharmacology - 10 Feb 2020

Naidoo D, Roy A, Slavětínská L Poštová, Chukwujekwu J C, Gupta S, Van Staden J

Abstract excerpt

ETHNOPHARMACOLOGICAL RELEVANCE: The development of selective inhibitors of monoamine oxidase B (MAO-B) has been essential in treating Parkinson's disease. However, the apparent hepatotoxicity and drug-drug interactions of current inhibitors accentuate the need for the development of novel pharmacotherapies. Crossyne guttata (L.) D. & U. Müll-Doblies is used frequently by Rastafarian bush doctors to treat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Docking Simulation

Share to Monoamine Oxidase

Share to Risk Assessment

Share to Salmonella typhimurium

Share to Structure-Activity Relationship

Share to Vero Cells

Source

Identifiers

PMID: 31639490
DOI: 10.1016/j.jep.2019.112305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New role for crinamine as a potent, safe and selective inhibitor of human monoamine oxidase B: In vitro and in silico pharmacology and modeling.PMID 31639490Read ↗

Alkaloid Profiling and Anti-Cholinesterase Potential of Three Different Genera of Amaryllidaceae Collected in Ecuador: <em>Urceolina</em> Rchb., <em>Clinanthus</em> Herb., and <em>Stenomesson</em> HerbSemantic proximity Read ↗

A critical Review on the Neuropharmacological Effects of Kratom: An Insight from the Functional Array of Identified Natural CompoundsSemantic proximity Read ↗

Monoamine Oxidases (MAOs) as Privileged Molecular Targets in Neuroscience: Research Literature AnalysisSemantic proximity Read ↗

Medicinal Cannabis - Potential Drug InteractionsSemantic proximity Read ↗

Evaluation of Cholinesterase Inhibitory Potential of Different Genotypes of Ziziphus nummularia, Their HPLC-UV, and Molecular Docking Analysis.Semantic proximity Read ↗

Acetylcholinesterase Inhibitory Potential of Plant-Based Phenolics in the Treatment of Alzheimer's Disease: An In Silico ApproachSemantic proximity Read ↗

Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico , In Vitro , and In Vivo ApproachesSemantic proximity Read ↗

Sedative Potential of Catha edulis Forsk: Exploring In Vivo Model, Gene Expression, Molecular Docking, and GABAergic Pathway InvolvementSemantic proximity Read ↗

Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602.Semantic proximity Read ↗

Exploring Novel Pharmacotherapy Candidates for Cannabis Use Disorder: Uncovering Promising Agents on the Horizon by Mechanism of ActionSemantic proximity Read ↗

KDS2010, a newly developed reversible MAO-B inhibitor, as an effective therapeutic candidate for Parkinson’s diseaseSemantic proximity Read ↗

Bioavailability and Neuroprotectivity of 3-(3, 4-dimethoxy phenyl)-1-4 (methoxy phenyl) prop-2-en-1-one against Schizophrenia: an in silico approach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.