Article
TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 2013
Liu Mohan, Ingle James N, Fridley Brooke L, Buzdar Aman U, Robson Mark E, Kubo Michiaki, Wang Liewei, Batzler Anthony, Jenkins Gregory D, Pietrzak Tracy L, Carlson Erin E, Goetz Matthew P, Northfelt Donald W, Perez Edith A, Williard Clark V, Schaid Daniel J, Nakamura Yusuke, Weinshilboum Richard M
Abstract excerpt
We performed a discovery genome-wide association study to identify genetic factors associated with variation in plasma estradiol (E2) concentrations using DNA from 772 postmenopausal women with estrogen receptor (ER)-positive breast cancer prior to the initiation of aromatase inhibitor therapy. Association analyses showed that the single nucleotide polymorphisms (SNP) (rs1864729) with the lowest P value (P =...
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