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The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors

13 Oct 2009

Abstract excerpt

During the co-evolution of cytomegalovirus (CMV) and natural killer (NK) cells, each has evolved specific tactics in an attempt to prevail. CMV has evolved multiple immune evasion mechanisms to avoid detection by NK cells and other immune cells, leading to chronic infection. Meanwhile, the host has evolved virus-specific receptors to counter these evasion strategies. The natural selection of viral genes and host...

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PMID: 20151027
DOI: 10.3390/v1030362

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