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Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host

14 Oct 2019

Abstract excerpt

Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host−pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of Staphylococcus aureus siderophores across...

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PMID: 31611408
DOI: 10.1073/pnas.1913991116

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