Article
Mutagenicity and chemical reactivity of epoxidic intermediates of the isoprene metabolism and other structurally related compounds.
Mutation research - 1 Jan 2000
Gervasi P G, Citti L, Del Monte M, Longo V, Benetti D
Abstract excerpt
The mutagenic activities of the epoxidic intermediates of the isoprene biotransformation were investigated using Salmonella typhimurium and compared with those of other structurally related epoxides. The compound 2-methyl-1,2,3,4-diepoxybutane, chemically analogous to the well known carcinogenic 1,2,3,4-diepoxybutane, was found to be as mutagenic as the latter. Moreover, the mutagenic activities of oxiranes were...
Topics
- Biotransformation
- Butadienes
- Epoxy Compounds
- Ethers, Cyclic
- Hemiterpenes
- Kinetics
- Mutation
- Niacinamide
- Pentanes
- Salmonella typhimurium
- Structure-Activity Relationship