Article

Predictors of Cognitive Decline in Healthy Middle-Aged Individuals with Asymptomatic Alzheimer’s Disease

2023-02-28

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) progresses through a lengthy asymptomatic period during which pathological changes accumulate prior to development of clinical symptoms. As disease-modifying treatments are developed, tools to stratify risk of clinical disease will be required to guide their use. In this study, we examine the relationship of AD biomarkers in healthy middle-aged individuals to he...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71513206-0b3e-51c4-9eb7-2e4b86e94aee
DOI: 10.21203/rs.3.rs-2577025/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Predictors of Cognitive Decline in Healthy Middle-Aged Individuals with Asymptomatic Alzheimer’s DiseaseDOI 10.21203/rs.3.rs-2577025/v1Read

Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbiditiesSemantic proximity Read

Blood-Based Biomarkers in Alzheimer's Disease: Advancing Non-Invasive Diagnostics and PrognosticsSemantic proximity Read

Identification of a simple and novel cut-point based CSF and MRI signature for predicting Alzheimer’s disease progression that reinforces the 2018 NIA-AA research frameworkSemantic proximity Read

Soluble Amyloid-Beta Isoforms Predict Downstream Alzheimer’s Disease PathologySemantic proximity Read

Hypothesis: cerebrospinal fluid protein markers suggest a pathway toward symptomatic resilience to AD pathologySemantic proximity Read

Identification of Novel Biomarkers for Alzheimer’s Disease and Related Dementias Using Unbiased Plasma ProteomicsSemantic proximity Read

Cerebrospinal Fluid (CSF) Proteomic Signature in Preclinical and Clinical AD: Role of Adhesion Molecules.Semantic proximity Read

Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real‐world population‐based cohortSemantic proximity Read

Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease neuroimaging initiative (ADNI) plasma proteome dataset.Semantic proximity Read

Novel Plasma Protein Biomarkers: A Time-Dependent predictive model for Alzheimer's DiseaseSemantic proximity Read

Blood-Based RNA Biomarkers and Machine Learning Approaches for Alzheimer’s DiseaseSemantic proximity Read

Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer’s DiseaseSemantic proximity Read