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Article

Species specific differences in use of ANP32 proteins by influenza A virus

3 Jun 2019

Abstract excerpt

Influenza A viruses (IAV) are subject to species barriers that prevent frequent zoonotic transmission and pandemics. One of these barriers is the poor activity of avian IAV polymerases in human cells. Differences between avian and mammalian ANP32 proteins underlie this host range barrier. Human ANP32A and ANP32B homologues both support function of human-adapted influenza polymerase but do not support efficient...

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PMID: 31159925
DOI: 10.7554/elife.45066

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