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Article

Coordination of miR-192 and miR-22 in p53-Mediated Cell Fate Decision

26 Sept 2019

Abstract excerpt

p53-targeted microRNAs (miRNAs) markedly affect cellular response to DNA damage. These miRNAs may contribute to either cell cycle arrest or apoptosis induction. However, how these miRNAs coordinate to modulate the decision between cell survival and death remains less understood. Here, we developed an integrated model of p53 signaling network to investigate how p53-targeted miR-192 and miR-22 modulate cellular...

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PMID: 31561425
DOI: 10.3390/ijms20194768

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