MicroRNA-21 Affects Proliferation and Apoptosis by Regulating Expression of PTEN in Human Keloid Fibroblasts

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression in the progress of proliferation, differentiation, and apoptosis. A keloid is considered to be a type of benign tumor. The exact contribution of miRNAs in keloid fibroblasts remains largely unknown. METHODS: Loss and gain of function was used by transfecting the keloid fibroblast cells with chemically synthesized...

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