Article
Context is everything: aneuploidy in cancer.
Nature reviews. Genetics - 1 Jan 2020
Ben-David Uri, Amon Angelika
Abstract excerpt
Cancer is driven by multiple types of genetic alterations, which range in size from point mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome instability, the process that gives rise to aneuploidy, can promote tumorigenesis by increasing genetic heterogeneity and promoting tumour evolution. However, much less is known about how aneuploidy itself contributes to tumour formation and...
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