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Article

Targeting Histone Deacetylase 6 Reprograms Interleukin‐17‐Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma

20 Sept 2019

Abstract excerpt

Background and Aims Hepatocellular carcinoma (HCC) is often accompanied by resistance to immunotherapies despite the presence of tumor‐infiltrating lymphocytes. We report that histone deacetylase 6 (HDAC6) represses interleukin‐17 (IL‐17)–producing helper T (T H 17) cell pathogenicity and the antitumor immune response, dependent on its deacetylase activity. Approach and Results Adoptive transfer of...

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PMID: 31539182
DOI: 10.1002/hep.30960

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