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Article

Deletion of CD163 Exon 7 Confers Resistance to Highly Pathogenic Porcine Reproductive and Respiratory Viruses on Pigs

1 Jan 2019

Abstract excerpt

exon 7 deletion confers resistance to HP-PRRSV infection without impairing the biological functions of CD163.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31523199
DOI: 10.7150/ijbs.34269

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Related research

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Deletion of CD163 Exon 7 Confers Resistance to Highly Pathogenic Porcine Reproductive and Respiratory Viruses on PigsPMID 31523199Read ↗

CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus.Semantic proximity Read ↗

Generation of Pigs Resistant to Highly Pathogenic-Porcine Reproductive and Respiratory Syndrome Virus through Gene Editing of CD163Semantic proximity Read ↗

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function.Semantic proximity Read ↗

Pigs lacking the SRCR5 domain of CD163 protein demonstrate heritable resistance to the PRRS virus and no changes in animal performance from birth to maturitySemantic proximity Read ↗

CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses.Semantic proximity Read ↗

Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 InfectionSemantic proximity Read ↗

Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 InfectionSemantic proximity Read ↗

Genetically modified pigs lacking CD163 PSTII-domain-coding exon 13 are completely resistant to PRRSV infectionSemantic proximity Read ↗

Replacement of Porcine CD163 Scavenger Receptor Cysteine-Rich Domain 5 with a CD163-Like Homolog Confers Resistance of Pigs to Genotype 1 but Not Genotype 2 Porcine Reproductive and Respiratory Syndrome Virus.Semantic proximity Read ↗

Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for ControlSemantic proximity Read ↗

Identification of the CD163 Protein Domains Involved in Infection of the Porcine Reproductive and Respiratory Syndrome VirusSemantic proximity Read ↗

Porcine alveolar macrophage CD163 abundance is a pivotal switch for porcine reproductive and respiratory syndrome virus infectionSemantic proximity Read ↗

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