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CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus.

Antiviral research - 1 Mar 2018

Yang Huaqiang, Zhang Jian, Zhang Xianwei, Shi Junsong, Pan Yongfei, Zhou Rong, Li Guoling, Li Zicong, Cai Gengyuan, Wu Zhenfang

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) causes severe economic losses to current swine production worldwide. Highly pathogenic PRRSV (HP-PRRSV), originated from a genotype 2 PRRSV, is more virulent than classical PRRSV and further exacerbates the economic impact. HP-PRRSV has become the predominant circulating field strain in China since 2006. CD163 is a cellular receptor for PRRSV. The...

Topics

Animals
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Disease Resistance
Gene Editing
Genotype
Macrophages
Nuclear Transfer Techniques
Porcine Reproductive and Respiratory Syndrome
Porcine respiratory and reproductive syndrome virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Interaction Domains and Motifs

Receptors, Cell Surface

Swine

Viremia

CD163 Antigen

Source

Identifiers

PMID: 29337166
DOI: 10.1016/j.antiviral.2018.01.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus.PMID 29337166Read ↗

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