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Identification of the CD163 Protein Domains Involved in Infection of the Porcine Reproductive and Respiratory Syndrome Virus

24 Dec 2009

Abstract excerpt

Scavenger receptor CD163 is a key entry mediator for porcine reproductive and respiratory syndrome virus (PRRSV). To identify the CD163 protein domains involved in PRRSV infection, deletion mutants and chimeric mutants were created. Infection experiments revealed that scavenger receptor cysteine-rich (SRCR) domain 5 (SRCR 5) is essential for PRRSV infection, while the four N-terminal SRCR domains and the...

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PMID: 20032174
DOI: 10.1128/jvi.02093-09

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Identification of the CD163 Protein Domains Involved in Infection of the Porcine Reproductive and Respiratory Syndrome VirusPMID 20032174Read ↗

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