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Article

Generation of Pigs Resistant to Highly Pathogenic-Porcine Reproductive and Respiratory Syndrome Virus through Gene Editing of CD163

1 Jan 2019

Abstract excerpt

remarkably inhibited PRRSV replication and protected pigs from HP-PRRSV infection, thus establishing a good foundation for breeding PRRSV-resistant pigs via gene editing technology.

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 30745836
DOI: 10.7150/ijbs.25862

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Generation of Pigs Resistant to Highly Pathogenic-Porcine Reproductive and Respiratory Syndrome Virus through Gene Editing of CD163PMID 30745836Read ↗

CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus.Semantic proximity Read ↗

Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 InfectionSemantic proximity Read ↗

Gene editing as applied to prevention of reproductive porcine reproductive and respiratory syndromeSemantic proximity Read ↗

Pigs lacking the SRCR5 domain of CD163 protein demonstrate heritable resistance to the PRRS virus and no changes in animal performance from birth to maturitySemantic proximity Read ↗

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function.Semantic proximity Read ↗

Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 InfectionSemantic proximity Read ↗

CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance.Semantic proximity Read ↗

Deletion of CD163 Exon 7 Confers Resistance to Highly Pathogenic Porcine Reproductive and Respiratory Viruses on PigsSemantic proximity Read ↗

Pig macrophages with site-specific edited CD163 decrease the susceptibility to infection with porcine reproductive and respiratory syndrome virusSemantic proximity Read ↗

Genetic resistance - an alternative for controlling PRRS?Semantic proximity Read ↗

Generation of CD163-edited pig via electroporation of the CRISPR/Cas9 system into porcine in vitro-fertilized zygotesSemantic proximity Read ↗

Genome editing for disease resistance in pigs and chickensSemantic proximity Read ↗

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