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Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control

7 Apr 2021

Abstract excerpt

Cellular receptors play a critical role in viral infection. At least seven cellular molecules have been identified as putative viral entry mediators for porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data indicate that among these candidates, CD163, a cysteine-rich scavenger receptor on macrophages, is the major receptor for PRRSV. This review discusses the recent advances and...

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PMID: 33916997
DOI: 10.3390/vaccines9040354

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Related research

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Research trail→

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Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for ControlPMID 33916997Read ↗

Role of CD163 in PRRSV infectionSemantic proximity Read ↗

Identification of the CD163 Protein Domains Involved in Infection of the Porcine Reproductive and Respiratory Syndrome VirusSemantic proximity Read ↗

PRRS virus receptors and an alternative pathway for viral invasionSemantic proximity Read ↗

Porcine alveolar macrophage CD163 abundance is a pivotal switch for porcine reproductive and respiratory syndrome virus infectionSemantic proximity Read ↗

Structural comparison of CD163 SRCR5 from different species sheds some light on its involvement in porcine reproductive and respiratory syndrome virus-2 infection in vitro.Semantic proximity Read ↗

The Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection.Semantic proximity Read ↗

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function.Semantic proximity Read ↗

Mutations within scavenger receptor cysteine-rich (SRCR) protein domain 5 of porcine CD163 involved in infection with porcine reproductive and respiratory syndrome virus (PRRS).Semantic proximity Read ↗

Identification of CD163 regions that are required for porcine reproductive and respiratory syndrome virus (PRRSV) infection but not for binding to viral envelope glycoproteinsSemantic proximity Read ↗

Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 InfectionSemantic proximity Read ↗

A brief review of CD163 and its role in PRRSV infectionSemantic proximity Read ↗

CD163-Expressing Porcine Macrophages Support NADC30-like and NADC34-like PRRSV InfectionsSemantic proximity Read ↗

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