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Article

CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses.

Journal of virology - 1 Jul 2007

Calvert Jay G, Slade David E, Shields Shelly L, Jolie Rika, Mannan Ramasamy M, Ankenbauer Robert G, Welch Siao-Kun W

Abstract excerpt

Direct functional screening of a cDNA expression library derived from primary porcine alveolar macrophages (PAM) revealed that CD163 is capable of conferring a porcine reproductive and respiratory syndrome virus (PRRSV)-permissive phenotype when introduced into nonpermissive cells. Transient-tran...

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Share to Antigens, CD
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17494075
DOI: 10.1128/JVI.00513-07
PMCID: PMC1933360

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17494075-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses.PMID 17494075Read ↗

Porcine alveolar macrophage CD163 abundance is a pivotal switch for porcine reproductive and respiratory syndrome virus infectionSemantic proximity Read ↗

Role of CD163 in PRRSV infectionSemantic proximity Read ↗

Establishment of an Immortalized Porcine Alveolar Macrophage Cell Line That Supports Efficient Replication of Porcine Reproductive and Respiratory Syndrome VirusesSemantic proximity Read ↗

Deletion of CD163 Exon 7 Confers Resistance to Highly Pathogenic Porcine Reproductive and Respiratory Viruses on PigsSemantic proximity Read ↗

CD163-Expressing Porcine Macrophages Support NADC30-like and NADC34-like PRRSV InfectionsSemantic proximity Read ↗

Pig macrophages with site-specific edited CD163 decrease the susceptibility to infection with porcine reproductive and respiratory syndrome virusSemantic proximity Read ↗

CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus.Semantic proximity Read ↗

The porcine reproductive and respiratory syndrome virus requires trafficking through CD163-positive early endosomes, but not late endosomes, for productive infectionSemantic proximity Read ↗

Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for ControlSemantic proximity Read ↗

Replacement of Porcine CD163 Scavenger Receptor Cysteine-Rich Domain 5 with a CD163-Like Homolog Confers Resistance of Pigs to Genotype 1 but Not Genotype 2 Porcine Reproductive and Respiratory Syndrome Virus.Semantic proximity Read ↗

Identification of the CD163 Protein Domains Involved in Infection of the Porcine Reproductive and Respiratory Syndrome VirusSemantic proximity Read ↗

Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function.Semantic proximity Read ↗

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