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Genetically modified pigs lacking CD163 PSTII-domain-coding exon 13 are completely resistant to PRRSV infection

1 Jan 2024

Abstract excerpt

CD163 expressed on cell surface of porcine alveolar macrophages (PAMs) serves as a cellular entry receptor for porcine reproductive and respiratory syndrome virus (PRRSV). The extracellular portion of CD163 contains nine scavenger receptor cysteine-rich (SRCR) and two proline-serine-threonine (PST) domains. Genomic editing of pigs to remove the entire CD163 or just the SRCR5 domain confers resistance to infection...

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PMID: 38184111
DOI: 10.1016/j.antiviral.2024.105793

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Genetically modified pigs lacking CD163 PSTII-domain-coding exon 13 are completely resistant to PRRSV infectionPMID 38184111Read ↗

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