Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment

13 Sept 2019

Abstract excerpt

BACKGROUND: Skin cutaneous melanoma (SKCM) is the most lethal form of skin cancer and while incidence rates are declining for most cancers, they have been steadily rising for SKCM. Serine protease inhibitor, kunitz-type, 1 (SPINT1) is a type II transmembrane serine protease inhibitor that has been shown to be involved in the development of several types of cancer, such as squamous cell carcinoma and colorectal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Polyamine Metabolism and Applications
Share to Renal cell carcinoma treatment
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31519199
DOI: 10.1186/s13046-019-1389-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironmentPMID 31519199Read ↗

SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironmentSemantic proximity Read ↗

A cross-scale multimodal framework identifies clinically actionable immunotherapy biomarkers in melanoma through bulk to single-cell and spatial transcriptomics integrationSemantic proximity Read ↗

Construction of a tumor mutational burden-derived LncRNA prognostic computational framework associated with therapy sensitivity in skin cutaneous melanoma.Semantic proximity Read ↗

Novel CRISPR-Cas9 BAP1 Knockout Pre-Clinical Tumor Model Recapitulates Human Melanoma Tumorigenesis and Immune EvolutionSemantic proximity Read ↗

Novel CRISPR-Cas9 BAP1 Knockout Pre-Clinical Tumor Model Recapitulates Human Melanoma Tumorigenesis and Immune EvolutionSemantic proximity Read ↗

Oronasal mucosal melanoma is defined by two transcriptional subtypes in humans and dogs with implications for diagnosis and therapySemantic proximity Read ↗

Anti-tumor immune response varies among individuals: A gene expression profiling of mouse melanoma.Semantic proximity Read ↗

YIF1B Mutational Dysregulation Drives Cutaneous Melanoma Progression by Remodeling the TME.Semantic proximity Read ↗

TEAD4 Drives SKCM Progression Through COL1A2 Transcriptional Activation and Modulation of AKT/mTOR Signalling and Necroptosis-Related Phenotypes.Semantic proximity Read ↗

Prognostic value and immune status of AIM2 in skin cutaneous melanomaSemantic proximity Read ↗

Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanomaSemantic proximity Read ↗

Bmal1 upregulates ATG5 expression to promote autophagy in skin cutaneous melanomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.