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Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma

1 Nov 2018

Abstract excerpt

Hunting and fishing for cancer genes Mucosal melanoma is a rare, but deadly, form of melanoma that occurs in sun-protected tissues. Little is known about the genetic alterations that drive the growth of these tumors. Ablain et al. sequenced mucosal melanomas from 43 patients and found that a substantial fraction showed inactivation or loss of SPRED1 , a gene that encodes a negative regulator of RAS–MAPK...

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PMID: 30385465
DOI: 10.1126/science.aau6509

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