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Disruption of cardiac thin filament assembly arising from a mutation in LMOD2 : A novel mechanism of neonatal dilated cardiomyopathy

4 Sept 2019

Abstract excerpt

-null mice, and remarkable morphological and functional similarities between the patient and mouse model informed the decision to pursue cardiac transplantation in the patient. To our knowledge, this is the first report of aberrant cardiac thin filament assembly associated with human cardiomyopathy.

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Identifiers

PMID: 31517052
DOI: 10.1126/sciadv.aax2066

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