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Article

WNT5a-Mediated Aberrant Actin Filament Dynamics Drive Cardiac Pathogenic Phenotypes in LMNA-Related Emery-Dreifuss Muscular Dystrophy.

Circulation - 2 Jun 2026

Fan Hangping, Wang Xiaochen, Liu Xujie, Zhao Jiuxiao, Zhang Yuan, Yang Zongkuai, Wang Hao, Gong Junhao, Li Lingying, Jin Jiamin, Guo Yuxuan, Gong Tingyu, Zhuang Lenan, Ke Qing, Liang Ping

Abstract excerpt

BACKGROUND: Emery-Dreifuss muscular dystrophy (EDMD) is a rare genetic disorder characterized by early-onset joint contractures, progressive muscle atrophy, and cardiac abnormalities. Patients with EDMD carrying LMNA sequence variations often exhibit severe cardiac manifestations, including frequent atrioventricular block and ventricular tachycardia. Approximately 20% of those patients may ultimately require...

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Share to Induced Pluripotent Stem Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscular Dystrophy, Emery-Dreifuss

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Source

Identifiers

PMID: 41993022
DOI: 10.1161/CIRCULATIONAHA.125.075604

Genes

LMNA
WNT5A

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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