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[Mutation analysis of 77 patients with normal-karyotype myelodysplastic syndrome].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 10 Sept 2019

Qin Wei, Chen Meiyu, Cai Xiaohui, Chao Hongying, Liu Jie, Jiang Naike, Zhou Min, Lu Xuzhang, Chen Suning, Zhang Ri, He Chuan, Wang Qian

Abstract excerpt

OBJECTIVE: To carry out mutation analysis for patients with myelodysplastic syndromes (MDS) and a normal karyotype. METHODS: Targeted capture and next-generation sequencing (NGS) was carried out using a customized 49-gene panel. FLT3 internal tandem duplication (FLT3-ITD), CALR, NPM1 and CEBPA mutations were detected by PCR and Sanger sequencing. RESULTS: Sixty-two patients (80.5%) were found to harbor at least...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31515775
DOI: 10.3760/cma.j.issn.1003-9406.2019.09.001

Genes

FLT3
ASXL1
DNMT3A
NPM1
RUNX1
U2AF1
BCOR
CALR
SF3B1

Provenance

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