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Article

Impact of gene alterations on clinical outcome in young adults with myelodysplastic syndromes.

Scientific reports - 14 Feb 2023

Konishi Tatsuya, Sadato Daichi, Toya Takashi, Hirama Chizuko, Kishida Yuya, Nagata Akihito, Yamada Yuta, Shingai Naoki, Shimizu Hiroaki, Najima Yuho, Kobayashi Takeshi, Haraguchi Kyoko, Okuyama Yoshiki, Harada Hironori, Ohashi Kazuteru, Harada Yuka, Doki Noriko

Abstract excerpt

Young adults with myelodysplastic syndrome (MDS) are rare, and the clinical significance of driver mutations has not yet been analysed. We analysed the gene mutations and copy number alterations (CNAs) in younger MDS patients using next-generation sequencing, targeting 68 genes that were recurrently mutated in myeloid malignancies, to investigate the correlation between their genetic alterations and clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36788335
DOI: 10.1038/s41598-023-29794-4
PMCID: PMC9929038

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