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Optimizing Modified mRNA In Vitro Synthesis Protocol for Heart Gene Therapy

30 Jul 2019

Abstract excerpt

Synthetic modified RNA (modRNA) is a novel vector for gene transfer to the heart and other organs. modRNA can mediate strong, transient protein expression with minimal induction of the innate immune response and risk for genome integration. modRNA is already being used in several human clinical trials, and its use in basic and translational science is growing. Due to the complexity of preparing modRNA and the...

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PMID: 31508439
DOI: 10.1016/j.omtm.2019.07.006

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