Article

Predicting Amyloid Positivity Through Proteomic and Machine Learning Approaches

2025-10-24

Abstract excerpt

<h4>Introduction</h4> Alzheimer’s disease is a progressive neurodegenerative disorder where early detection remains difficult. To address this challenge, we analysed a large proteomics dataset from older adults, including individuals diagnosed through clinical and imaging confirmation of brain amyloid deposition. We hypothesized that amyloid positivity could be detected using blood-based proteomic profiles combin...

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Literature Corpus work: e30d42c8-527d-5781-8068-cca7a25b23cf
DOI: 10.1101/2025.10.20.25337968

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