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Article

A cis‐eQTL genetic variant in PLK4 confers high risk of hepatocellular carcinoma

6 Sept 2019

Abstract excerpt

PURPOSE: The overexpression and knockdown of PLK4 were both reported to generate aneuploidy. Thus, we aimed to investigate whether genetic variants in PLK4 contribute to the development of hepatocellular carcinoma (HCC). METHODS: We evaluated associations of common variants in PLK4 and its promoter for the risk of HCC in our association study (1300 cases and 1344 controls). The genotype-tissue expression (GTEx)...

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PMID: 31489978
DOI: 10.1002/cam4.2487

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