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Article

Wnt status-dependent oncogenic role of BCL9 and BCL9L in hepatocellular carcinoma

22 Aug 2019

Abstract excerpt

BACKGROUND: Activation of Wnt/β-catenin pathway is a frequent event in hepatocellular carcinoma and is associated with enhanced cell survival and proliferation. Therefore, targeting this signaling pathway is discussed as an attractive therapeutic approach for HCC treatment. BCL9 and BCL9L, two homologous coactivators of the β-catenin transcription factor complex, have not yet been comprehensively characterized in...

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PMID: 31440992
DOI: 10.1007/s12072-019-09977-w

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