Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Correlation of LAGE3 with unfavorable prognosis and promoting tumor development in HCC via PI3K/AKT/mTOR and Ras/RAF/MAPK pathways

21 Mar 2022

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common clinical malignancies quite susceptible to recurrence and metastasis. Despite several improvements in therapeutic approaches, the prognosis remains poor due to the limited treatment options. A bioinformatics analysis based on TCGA databases revealed that the recombinant human L antigen family member 3 (LAGE3) might function as an effective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immunotherapy and Immune Responses
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35313850
DOI: 10.1186/s12885-022-09398-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Correlation of LAGE3 with unfavorable prognosis and promoting tumor development in HCC via PI3K/AKT/mTOR and Ras/RAF/MAPK pathwaysPMID 35313850Read ↗

LpCat1 Promotes Malignant Transformation of Hepatocellular Carcinoma Cells by Directly Suppressing STAT1Semantic proximity Read ↗

MiR-18a-5p promotes proliferation, migration and invasion of hepatocellular carcinoma by targeting CPEB3Semantic proximity Read ↗

The expression, immune infiltration, prognosis, and experimental validation of OSBPL family genes in liver cancerSemantic proximity Read ↗

PDCL3 is a Novel Oncogenic Indicator in Hepatocellular Carcinoma using Comprehensive Bioinformatics Analysis and in vitro ValidationSemantic proximity Read ↗

TNNI3 expression and prognostic value and correlation with tumor-infiltrating immune cells in LIHC: A bioinformatics analysisSemantic proximity Read ↗

Expression and clinical significance of LAG-3, FGL1, PD-L1 and CD8+T cells in hepatocellular carcinoma using Multiplex Quantitative AnalysisSemantic proximity Read ↗

Expression of IER3 in hepatocellular carcinoma: clinicopathology, prognosis, and potential regulatory pathwaysSemantic proximity Read ↗

The correlation of fibrinogen-like protein-1 expression with the progression and prognosis of hepatocellular carcinomaSemantic proximity Read ↗

Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcomaSemantic proximity Read ↗

Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinomaSemantic proximity Read ↗

CSTB accelerates the progression of hepatocellular carcinoma via the ERK/AKT/mTOR signaling pathwaySemantic proximity Read ↗

UBE2L3, a susceptibility gene that plays oncogenic role in hepatitis B-related hepatocellular carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.