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Article

IRX 5 promotes NF ‐κB signalling to increase proliferation, migration and invasion via OPN in tongue squamous cell carcinoma

15 May 2018

Abstract excerpt

Iroquois homeobox gene 5 (Irx5) is a highly conserved member of the Iroquois homeobox gene family. Members of this family play distinct and overlapping roles in normal embryonic cell patterning and development of malignancies. In this study, we observed that IRX5 was abnormally abundant in tongue squamous cell carcinoma (TSCC) tissues and cell lines. We used gain- and loss-of-function methods to overexpress and...

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PMID: 29761910
DOI: 10.1111/jcmm.13664

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