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Article

NRF 2/ ABCB 1‐mediated efflux and PARP 1‐mediated dampening of DNA damage contribute to doxorubicin resistance in chronic hypoxic HepG2 cells

17 Aug 2019

Abstract excerpt

Transarterial chemoembolization (TACE)-induced hypoxia can trigger residual liver cancer cells to present a more aggressive phenotype associated with chemoresistance, but the underlying mechanisms are still unknown. In this study, the human liver cancer cell line HepG2 was pre-cultured in different oxygen environments to examine the possible mechanisms of hypoxia-induced doxorubicin resistance. Our study showed...

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PMID: 31420991
DOI: 10.1111/fcp.12505

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